Annual report pursuant to Section 13 and 15(d)

Common Stock, Stock Options and Warrants (Details Textual)

v3.19.3.a.u2
Common Stock, Stock Options and Warrants (Details Textual)
1 Months Ended 12 Months Ended
Aug. 08, 2017
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Jun. 08, 2017
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Apr. 07, 2017
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Jan. 02, 2017
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Sep. 27, 2019
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Apr. 03, 2019
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Feb. 13, 2019
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Sep. 30, 2018
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Aug. 13, 2018
Apr. 02, 2018
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Mar. 29, 2018
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Feb. 07, 2018
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Dec. 19, 2017
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Nov. 07, 2017
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Jun. 29, 2017
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Feb. 28, 2017
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Feb. 28, 2017
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Sep. 30, 2019
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Sep. 30, 2018
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Sep. 30, 2017
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Sep. 30, 2016
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Jun. 07, 2017
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May 05, 2017
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Jan. 31, 2017
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Jun. 01, 2015
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Apr. 01, 2015
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Sep. 12, 2014
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Common Stock, Stock Options and Warrants (Textual)                                                        
Description of reverse stock split                                           1-for-15            
Common stock, shares issued | shares                 16,198,791                   28,930,493 16,198,791 8,345,844              
Common stock value | $                 $ 16,199                   $ 28,930 $ 16,199 $ 8,346              
Stock-based compensation | $                                     715,983 $ 779,701 $ 986,620              
Proceeds for research and development | $                                     741,843                  
Additional warrant purchase | shares                                 12,802                      
Number of additional units sold | shares                                         128,017              
Number of unit offering per share price | $ / shares                                         $ 6.00              
Warrant issued to placement agent | $                                 $ 58,759                      
Warrants issue | shares   140,819                                                    
Fair value of warrants recorded as derivative warrant liability | $                                       $ 641,385              
Stock issued for services and settlements | $                                         $ 491,351              
Common stock, par value | $ / shares                 $ 0.001                   $ 0.001 $ 0.001 $ 0.001              
Fees and commissions | $                                     $ 90,000 $ 75,000 $ 50,000              
Stock option purchase grants | shares                                     1,090,799                  
Stock option average vest term                                       2 years 3 months 19 days                
Prepaid expenses | $                                     $ (9,621) $ (162,514) (572,098)              
Warrants sold and issued to investors | $                 $ 10,000                     10,000                
Common stock issued for services fair value | $                                     211,597   704,019              
Other expense | $                                       75,000 50,000 $ 45,000            
Description of warrants         (i) 6,760,615 units, each unit consisting of one share of common stock and one immediately exercisable five-year warrant to purchase one share at $0.77 per share, and (ii) 1,060,615 pre-funded units, each pre-funded unit consisting of one pre-funded warrant to purchase one share and one immediately exercisable five-year warrant to purchase one share at $0.77 per share. The pre-funded warrants included in the pre-funded units are immediately exercisable at a price of $0.0001 per share and do not expire. The offering price was $0.8951 per unit and $0.895 per pre-funded unit. The net proceeds of the offering were $6,290,335. The Company issued the underwriter immediately exercisable five-year warrants to purchase up to 547,486 shares at $1.118875 per share with an estimated fair value of $323,414. The estimated fair value of the 1,060,615 pre-funded warrants was $809,145, and the estimated fair value of the 7,821,230 warrants included in the units and the pre-funded units issued to the investors was $4,845,341.         (i) 5,521,569 units, each unit consisting of one share of common stock and one immediately exercisable five-year warrant to purchase one share at $1.15 per share, and (ii) 2,321,569 pre-funded units, each pre-funded unit consisting of one pre-funded warrant to purchase one share and one immediately exercisable five-year warrant to purchase one share at $1.15 per share. The pre-funded warrants included in the pre-funded units are immediately exercisable at a price of $0.01 per share and do not expire. The offering price was $1.275 per unit and $1.265 per pre-funded unit. The net proceeds of the offering were $8,926,786. The Company issued underwriter warrants to purchase up to 549,020 shares at $1.59375 per share with an estimated fair value of $491,737. The underwriter warrants are exercisable following February 8, 2019 and expire on August 8, 2023. The estimated fair value of the 2,321,569 pre-funded warrants was $2,630,072, and the estimated fair value of the 7,843,138 warrants included in the units and the pre-funded units issued to the investors was $7,311,727.                                    
Proceeds from common stock warrant exercises | $                                     $ 23,216 $ 1,125,148            
Weighted average period                                     1 year 7 months 28 days                  
weighted average remaining life of all of the outstanding warrants                                     3 years 7 months 17 days                  
Aggregate intrinsic value for the warrants outstanding | $                                     $ 805,961                  
Maximum [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Exercise price of warrants | $ / shares                                     $ 1.27                  
Minimum [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Exercise price of warrants | $ / shares                                     $ 0.94                  
2017 Public Offering [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Common stock issued for services | shares                             100,000                          
Common stock issued for services fair value | $                             $ 60,000                          
Underwriter payment, restricted common stock fair value | $                             257,400                          
Other expense | $                             $ 357,400                          
Registered Direct and Private Placement Offering [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Exercise price of warrants | $ / shares             $ 1.42             $ 2.86                            
Warrants sold and issued to investors | $                           $ 420,566                            
Warrants issued | shares                           89,625                            
Percentage of offering fee                           7.00%                            
Term of warrants                           5 years                            
Stock Options [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Common stock outstanding | shares                 1,601,039                   1,771,039 1,601,039                
Weighted-average remaining contractual term, exercisable                                     7 years 1 month 9 days                  
Stock options to purchase exercised | shares                                                      
Aggregate intrinsic value for the warrants outstanding | $                                     $ 49,465                  
Share-based payment award, description                 In September 2018, the Board of Directors granted stock options to purchase a total of 520,000 shares to six employees, 75,000 options to five directors, and 80,000 options to three consultants at $1.62 per share.                                      
Omnibus Stock Incentive Plan [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Common stock, shares issued | shares                         2,000,000                              
Stock option purchase grants | shares                                     1,085,000                  
Financial advisor warrants exercised | shares                                     915,000                  
Private Offering [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Settlement expense | $                                         $ 161,771              
Issuance of common stock in private placement, net of costs, shares | shares                                         58,191              
Stock Options [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Stock options to purchase exercised | shares                                                      
Purchase Options Units [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Other expense | $                                       $ 96,930 $ 96,930              
Employee [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Stock options to purchase exercised | shares                                     165,000                  
Stock option estimated fair value, shares | shares                                     0.94                  
Accredited Investors [Member] | Registered Direct and Private Placement Offering [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Number of units sold | shares                       669,504   1,280,360                            
Exercise price of warrants | $ / shares                           $ 4.6925                            
Warrants sold and issued to investors | $             $ 5,300,001         $ 1,998,469   $ 6,008,089                            
Sale of common stock | shares                       669,504   1,280,360                            
Investor [Member] | Registered Direct and Private Placement Offering [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Number of units sold | shares             3,430,421         669,504                                
Exercise price of warrants | $ / shares                           $ 5.8656                            
Amendements to fair value of warrants | $             $ 3,430,421         $ 669,504                                
Warrants sold and issued to investors | $             $ 2,709,467         $ 1,679,482                                
Sale of common stock | shares             3,430,421         669,504                                
Description of warrants                           The Company sold the investors 640,180 immediately exercisable five and a half year warrants at $4.63 per share.                            
Warrants issued | shares                           640,180                            
Estimated fair value of the warrant granted to the placement agent | $                           $ 2,407,276                            
Placement Agent [Member] | Registered Direct and Private Placement Offering [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Number of units sold | shares             3,430,421         669,504                                
Number of units sold for gross proceeds | $                       $ 46,866                                
Sale of stock price | $ / shares             $ 1.545         $ 2.985                                
Other cash expenses related to placements | $             $ 85,000         $ 85,000   85,000                            
Warrants sold and issued to investors | $             169,854         110,511   5,482,523                            
Other expense | $             $ 10,000         $ 10,000   $ 20,000                            
Sale of common stock | shares             3,430,421         669,504                                
Description of warrants             The Company paid the placement agent a fee of 7% of the gross proceeds totaling $371,000 and issued the placement agent 240,130 immediately exercisable two-year warrants with an exercise price of $1.93125 per share.         The Company paid the placement agent a fee of 7% of the gross proceeds totaling $139,893 and issued the placement agent 46,866 immediately exercisable five-year warrants at $3.73125 per share.                                
Warrants issued | shares             240,130         46,866   89,625                            
Percentage of offering fee             7.00%         7.00%                                
Term of warrants             2 years         5 years                                
Estimated fair value of the warrant granted to the placement agent | $                           $ 316,071                            
Proceeds from common stock warrant exercises | $             $ 4,834,001         $ 1,763,576                                
Executive Chairman [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Common stock exercise price per share | $ / shares       $ 10.05                                 $ 3.45              
Stock options to purchase exercised | shares       8,669                             25,000 520,000 225,000              
Stock option purchase grants | shares                                       80,000 50,000              
Weighted average grant-date estimated per share | $ / shares                                       $ 1.75                
Stock option average vest term       10 years                             10 years 10 years 10 years              
Stock option estimated fair value, shares | shares       8.41                             1.04 1.45 2.95              
Number of consultants | Consultants       4                             4 3 2              
Options vest, description       These options vest over terms of 12 to 36 months and have a term of 10 years.                             These options vest over terms of 12 to 36 months and have a term of 10 years. These options vest over terms of 12 to 36 months and have a term of 10 years. These options vest over terms of 12 to 36 months and have a term of 10 years.              
Executive Chairman [Member] | Stock Options [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Common stock exercise price per share | $ / shares                                                   $ 9.00 $ 9.00  
Leonard Meron Biosciences [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Common stock, shares issued | shares                                               11,400        
Common stock value | $                                               $ 77,748        
Settlement expense | $                                         $ 77,748              
Financial Consultant [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Stock options to purchase exercised | shares                                       70,000                
Purchase Options Units [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Common stock exercise price per share | $ / shares     $ 9.00                         $ 9.00                        
Warrants outstanding purchase of common stock, shares | shares                               193,860         104,138              
Number of unit purchase | shares     38,000                         62,667                        
Number of units purchase, per unit | $ / shares     $ 9.00                         $ 9.00                        
Common Stock [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Common stock, shares issued | shares                                                       866,667
Stock-based compensation | $                                                  
Stock issued for services and settlements | $                                         $ 128              
Issuance of common stock in private placement, net of costs, shares | shares                                         128,016              
Stock options to purchase exercised | shares                                         4,829              
Stock option purchase grants | shares                                       5,799                
Number of consultants | Consultants                         2                              
Common stock issued for services | shares           94,097   125,000     10,000   22,200           219,097   140,843              
Common stock issued for services fair value | $           $ 94,097   $ 117,500     $ 31,000   $ 88,800           $ 219   $ 141              
Financial advisor warrants exercised | shares                 4,829                     4,829                
Retained Earnings [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Stock-based compensation | $                                                  
Stock issued for services and settlements | $                                                      
Common stock issued for services fair value | $                                                    
Additional Paid-in Capital [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Stock-based compensation | $                                     715,983 $ 779,701 986,620              
Stock issued for services and settlements | $                                         491,223              
Common stock issued for services fair value | $                                     $ 211,378   703,878              
Preferred Stock [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Stock-based compensation | $                                                      
Stock issued for services and settlements | $                                                      
Stock options to purchase exercised | shares                                                      
Common stock issued for services | shares                                                      
Common stock issued for services fair value | $                                                    
Warrant [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Exercise of outstanding warrants | $                                     $ 25,492,513                  
2017 Public Offering and Release Agreement [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Number of unit offering per share price | $ / shares $ 4.125                                                      
Exercise price of warrants | $ / shares $ 4.125                                                      
Share issued | shares 1,648,484                                                      
Weighted-average remaining contractual term, exercisable 5 years                                                      
Warrants to purchase | shares 1,648,484                                                      
Warrants to purchase of common stock price per share | $ / shares $ 0.01                                                      
2017 Public Offering [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Issuance of common stock in private placement, net of costs, shares | shares 58,191                                                      
Common stock, par value | $ / shares $ 4.125                                                      
2017 Public Offering [Member] | Common Stock [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Stock sold for gross proceeds | $ $ 6,802,469                                                      
Unit purchase options, description The Company granted the underwriters a 45-day option to purchase up to an additional 247,272 shares of common stock and warrants to purchase 247,272 shares of common stock to cover over-allotments, if any. On August 8, 2017, the underwriters partially exercised the over-allotment to purchase an additional 247,272 warrants. The estimated fair value of the 1,895,756 warrants issued to the investors was $4,160,195 and the estimated fair value of the 65,940 warrants issued to the underwriters was $142,419.                                                      
Common stock, par value | $ / shares $ 4.125                                                      
Fees and commissions | $ $ 685,573                                                      
Weighted-average remaining contractual term, exercisable 5 years                                                      
Investor Warrants [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Common stock, shares issued | shares                                                 29,729      
Warrants issue | shares                                 128,017 128,017                    
Fair value of common stock | $                                   $ 587,592     298,774              
Common stock outstanding | shares                 202,469                     202,469                
Stock option estimated fair value | $                                         $ 4,160,195              
Stock option estimated fair value, shares | shares 1,895,756                                                      
Offering Warrants [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Warrants outstanding purchase of common stock, shares | shares                                         12,802              
Additional warrant purchase | shares                                 12,802       12,802              
Number of units sold | shares                                 128,017                      
Number of units sold, per unit | $ / shares                                 $ 6.00                      
Number of units sold for gross proceeds | $                                 $ 768,100                      
Expense allowance, percentage                                 3.00%                      
Percentage of cash commission on gross proceeds                                 10.00%                      
Warrants issue | shares                 272,767                     272,767                
Exercise price of warrants | $ / shares   $ 4.125             $ 4.25                     $ 4.25                
Sale of common stock | shares                                 128,017                      
Proceeds from common stock warrant exercises | $                                       $ 1,125,148                
Placement Agent Unit Warrants [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Number of units sold | shares                                 128,017                      
Expense allowance | $                                 $ 99,853                      
Warrant offering description                                 The Company sold 128,017 units at $6.00 per unit for gross proceeds of $768,100. Each unit consisted of (i) one share of common stock and (ii) a five-year warrant to purchase one share of common stock at an exercise price of $8.25 per share. The placement agent received a 10% cash commission on the gross proceeds, an expense allowance equal to 3% of the proceeds, and warrants to purchase 12,802 shares of common stock at an exercise price of $8.25 per share. The estimated fair value of the 128,017 warrants issued to the investors was $587,592 and the estimated fair value of the 12,802 warrants issued to the placement agent was $58,759. The placement agent commissions and expense allowance was $99,853. Other costs of the placement were $176,896.                      
Warrants issue | shares                                         12,802              
Fair value of common stock | $                                 $ 587,592                      
Other cost | $                                 $ 176,896                      
Sale of common stock | shares                                 128,017                      
Underwriters [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Stock option estimated fair value | $                                         $ 142,419              
Stock option estimated fair value, shares | shares                                         65,940              
Offering [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Common stock, shares issued | shares                                             6,668          
Common stock value | $                                             $ 45,476          
Settlement expense | $                                         $ 45,476              
Description of release agreements   In exchange, the Company agreed that (i) in the event that a financing is conducted at a price per share or price per unit lower than $6.00, then the Company will issue additional shares to each investor sufficient to effectively reprice the sale of the 2016 Offering units to the lower price; (ii) in the event that the financing is conducted at a price per share or price per unit less than the $8.25 exercise price of the warrants issued in the 2016 Offering then the exercise price of the warrants shall be reduced to the lower price; and (iii) the Company will give each investor no less than 6 hours of notice before the closing of any subsequent financing, through and including the Company's 2017 registered public offering, and each investor shall have a 6-hour option to purchase up to 20% of the securities sold in such offering. In connection with these agreements the Company reclassified the $641,385 fair value of the 140,819 warrants issued in the 2016 Offering to derivative warrant liability on June 8, 2017. On August 8, 2017, the Company completed its 2017 public offering and issued 58,191 shares of common stock to the investors in the 2016 Offering to reprice the sale of the 2016 Offering units to $4.125 per unit and repriced the 2016 Offering Warrants to an exercise price of $4.125 per share. During the year ended September 30, 2017, the Company recorded a settlement expense of $161,771 in connection with the issuance of the additional 58,191 shares of common stock and reclassified the current fair value of the warrants to additional paid-in capital.                                                    
Warrants outstanding purchase of common stock, shares | shares   140,819                                                    
Exercise price of warrants | $ / shares $ 4.125                                                      
Offering pre-Funded [Member]                                                        
Common Stock, Stock Options and Warrants (Textual)                                                        
Warrants issue | shares                                     2,321,569                  
Exercise price of warrants | $ / shares                                     $ 0.01                  
Proceeds from common stock warrant exercises | $                                     $ 23,216